Biological sciences
Asifa Bibi; Nabeela Tariq; Hamida Ali; Zil-e-Huma Butt; Tasleem Kausar; Maqsood Maryam
Abstract
KEL1 (Kell or K) is highly immunogenic with limited distribution while KEL2 (Cellano or k) antigen is more prevalent. The antigenic diversity in the Kell gene is a result of Single Nucleotide Polymorphisms (SNPs). Blood samples of 160 males and females from each ethnic group with no age restrictions ...
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KEL1 (Kell or K) is highly immunogenic with limited distribution while KEL2 (Cellano or k) antigen is more prevalent. The antigenic diversity in the Kell gene is a result of Single Nucleotide Polymorphisms (SNPs). Blood samples of 160 males and females from each ethnic group with no age restrictions were subjected to Tetra-ARMS PCR to genotype the SNP (C578T) on exon 6 of chromosome 7. Genotype and allele frequencies were estimated in correlation with gender, age, and ethnicity with p-value less than 0.05. In general, antigen KEL2 k was more prevalent than antigen KEL1 k.
